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- CD4+T cell secretion of interferon-g leading to macrophage activation.
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- The induction phase of a cell-mediated immune response includes which of the following events?.
- It is true that DTH reactions involve the same cells and molecules as does CMI. Delayed-type hypersensitivity (DTH), like all hypersensitivity reactions, causes tissue damage and disease, but not protection.
Immunodeficiency states in which CMI is impaired (e.g., AIDS) result in infections by viruses and intracellular bacteria or fungi. These organisms include microbes that are phagocytosed and viruses that replicate in the cytoplasm. CMI is required for protection against microbes that can reside within cells and therefore are inaccessible to antibodies. Serum is a cell-free fraction of blood that includes antibodies, and therefore serum transfer can provide passive humoral immunity. The original definition of cell-mediated immunity (CMI), which is still valid, is protection against infection that can be transferred by T cells but not by serum.
- Phagocytes are essential in the effector phase of CMI responses to bacteria such as Listeria monocytogenes.
- The principal form of CMI that protects against viral infections is mediated by CD8+cytolytic T lymphocytes.
- Delayed-type hypersensitivity (DTH) is not a protective response against intracellular bacteria such as Mycobacterium tuberculosis.
- CMI can be adoptively transferred by injecting serum from one individual to another.
- Deficiencies in CMI result in susceptibility to infections by viruses and intracellular bacteria.
- Which of the following statements about cell-mediated immunity (CMI) is NOT true?.
- Abbas – Test BankĬhapter 06: Effector Mechanisms of T Cell–Mediated Immunity Description INSTANT DOWNLOAD WITH ANSWERS Basic Immunology Functions And Disorders of the Immune System 4th Edition by Abul K.